Jihye Yang

Jihye Yang is the lab operations manager and one of the lab’s longest-serving members. Jihye contributed to studies of the adenylation of maternally inherited microRNAs by Wispy (Molecular Cell, 2014), the single-nucleotide precision of primary microRNA processing (Molecular Cell, 2019), the roles of ERH (Nucleic Acids Research, 2020) and of DROSHA’s proline-rich disordered domain (Genes & Development, 2023) in microRNA maturation, viral hijacking of the TENT4–ZCCHC14 complex for mixed tailing (Nature Structural & Molecular Biology, 2020), and the functional viromic screens that uncovered regulatory RNA elements (Cell, 2023).

Education

• 2010–2012 M.S. in Microbiology, Ewha Womans University
• 2006–2010 B.S. in Chemistry, Duksung Women’s University

Publications with our lab

• SARS-CoV-2 Nsp2 recruits GIGYF2 near viral replication sites and supports viral protein production
  J. Kim¹, Y. Park¹, D. Yoon¹, S. Lee¹, H. Kim¹, K.-Y. Ban, J. Yang, D.-E. Choi, J. Kim, J.-S. Kim, and V. N. Kim^{✉︎ (corresponding author)}
  Nucleic Acids Research (2025), 53(14):gkaf674
• Functional viromic screens uncover regulatory RNA elements
  J. J. Seo¹, S.-J. Jung¹, J. Yang, D.-E. Choi, and V. N. Kim^{✉︎ (corresponding author)}
  Cell (2023), 186(15):3291-3306.e21
• Role of the proline-rich disordered domain of DROSHA in intronic microRNA processing
  S. Son¹, B. Kim¹, J. Yang, and V. N. Kim^{✉︎ (corresponding author)}
  Genes & Development (2023), 37(9-10):383-397
• ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8
  S. C. Kwon¹, H. Jang¹, S. Shen¹, S. C. Baek, K. Kim, J. Yang, J. Kim, J.-S. Kim, S. Wang, Y. Shi, F. Li^{✉︎ (corresponding author)}, and V. N. Kim^{✉︎ (corresponding author)}
  Nucleic Acids Research (2020), 48(19):11097-11112
• Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing
  D. Kim¹, Y. Lee¹, S.-J. Jung¹, J. Yeo¹, J. J. Seo, Y.-Y. Lee, J. Lim, H. Chang, J. Song, J. Yang, J. S. Kim, G. Jung, K. Ahn, and V. N. Kim^{✉︎ (corresponding author)}
  Nature Structural & Molecular Biology (2020), 27(6):581-588
• Molecular basis for the single-nucleotide precision of primary microRNA processing
  S. C. Kwon, S. C. Baek, Y. G. Choi, J. Yang, Y. Lee, J.-S. Woo^{✉︎ (corresponding author)}, and V. N. Kim^{✉︎ (corresponding author)}
  Molecular Cell (2019), 73(3):505-518.e5
• Adenylation of maternally inherited microRNAs by Wispy
  M. Lee, Y. Choi, K. Kim, H. Jin, J. Lim, T. A. Nguyen, J. Yang, M. Jeong, A. J. Giraldez, H. Yang, D. J. Patel, and V. N. Kim^{✉︎ (corresponding author)}
  Molecular Cell (2014), 56(5):696-707